乳腺癌疫苗:一个全面和更新的审查
Sulieman Ibraheem Shelash Al-Hawary1, Ebraheem Abdu Musad Saleh2, Nodirjon Akhmetovich Mamajanov3
1Al al-Bayt University, P.O.BOX 130040, Mafraq 25113, Jordan.
Pathology, research and practice
|August 23, 2023
概括
乳腺癌疫苗表现出有限的成功,但结合免疫检查点抑制剂或抗HER2抗体的新策略显示出加强对抗癌症的免疫反应的希望.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 乳腺癌是全球领先的癌症,预计到2040年死亡率将增加.
- 尽管目前的治疗方法,乳腺癌的转移和复发仍然难以治疗.
- 癌症疫苗通过刺激对瘤细胞的长期免疫反应提供了一个有希望的方法.
研究的目的:
- 审查乳腺癌疫苗开发的现状和挑战.
- 探索提高乳腺癌疫苗疗效的新策略.
- 突出免疫检查点抑制剂和抗HER2抗体在疫苗接种中的潜力.
主要方法:
- 审查涉及DNA,树突细胞和基于的乳腺癌疫苗的临床试验.
- 对各种施用途径的分析,包括皮下,肌内和皮内注射.
- 检查新兴的疫苗开发方法.
主要成果:
- 以前的乳腺癌疫苗试验没有显示出显著的优势.
- 疫苗开发的挑战包括免疫系统的复杂性和乳腺癌的异质性.
- 新兴战略显示了提高疫苗有效性的潜力.
结论:
- 尽管过去的挑战,研究乳腺癌疫苗正在进行中.
- 将疫苗与免疫检查点抑制剂或抗HER2单克隆抗体结合使用可能会提高疗效.
- 对量身定制的疫苗接种策略进行进一步的研究是有必要的,以改善乳腺癌的治疗.
更多相关视频
13:19Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
Published on: April 26, 2024
2.7K
07:33Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
Published on: September 28, 2022
1.8K
相关概念视频
Cancer Vaccines
400
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
400
Tumor Immunotherapy
556
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
556
Vaccinations
44.7K
Overview
44.7K
Cancer
48.7K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
48.7K
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
