[酒精性肝炎 - 目前和未来的治疗方法]
Philipp Kasper1, Münevver Demir2
1Klinik für Gastroenterologie und Hepatologie, Universitätsklinikum Köln, Köln, Deutschland.
Deutsche medizinische Wochenschrift (1946)
|August 23, 2023
概括
急性严重酒精性肝炎的预后不好,但针对炎症,肠肝轴和肝脏再生的新疗法显示出改善患者结果的希望.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 微生物组研究的研究.
背景情况:
- 急性严重酒精性肝炎是一种严重的肝病,死亡率高.
- 目前的治疗选择效果有限,需要新的治疗策略.
研究的目的:
- 审查目前对酒精性肝炎的管理策略.
- 探索新兴的治疗方法来改善患者的预后.
主要方法:
- 对酒精性肝炎的当前和试验性治疗方法的文献综述.
- 对驱动酒精性肝炎进展的病理机制的分析.
- 针对炎症,肠肝轴和肝细胞再生的新型治疗剂的概述.
主要成果:
- 研究中的疗法包括抗炎药物 (例如,互白素-1 抑制剂).
- 目前正在探索通过便微生物群转移或rifaximin调节肠肝轴.
- 肝细胞再生增强剂,如互白素-22激动剂,正在研究中.
结论:
- 更好地了解酒精性肝炎的发病因子正在推动创新的治疗开发.
- 新的治疗方式有可能显著改善严重酒精性肝炎的预后.
- 未来的研究重点是针对性疗法,以减少炎症并促进肝脏的修复.
相关概念视频
Chronic Pancreatitis II: Collaborative Care
113
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
113
CNS Depressants: Alcohol and Nicotine
243
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
243
Esophageal Varices-II: Clinical Features and Management
94
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
94
Diseases of the Liver and Gallbladder
629
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
629
Gastritis III: Clinical Manifestations and Management
322
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
322
Alzheimer's Disease: Treatment
213
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
213


