勒沃诺格斯特勒宫内器械和抑郁症:瑞典基于登记的队列研究
Elin Stenhammar1, Per Wikman1, Kristina Gemzell Danielsson2
1Department of Women's and Children's Health, Uppsala University, 751 85 Uppsala, Sweden.
概括
莱沃诺格斯特勒宫内器械 (LNG-IUD) 与57%的抑郁症风险增加有关,特别是在青少年和那些使用它作为第一种避孕药的人群中. 需要进一步的研究来确认因果关系.
科学领域:
- 生殖健康 生殖健康
- 心理健康 心理健康
- 药物监督 药物监督 药物监督
背景情况:
- 传统上被认为是安全的,具有最小的系统性影响的Levonorgestrel宫内装置 (LNG-IUD).
- 新出现的证据表明,LNG-IUD使用与抑郁症风险增加之间存在潜在的关联.
- 这项研究调查了LNG-IUD-抑郁症的联系,并确定了有风险的人群.
研究的目的:
- 为了检查LNG-IUD使用与抑郁症之间的关联.
- 确定增加LNG-IUD用户抑郁风险的特定人口或使用因素.
- 为了解LNG-IUD在心理健康方面的安全概况做出贡献.
主要方法:
- 使用瑞典国家人口登记册 (2010-2017年) 进行的纵向队列研究.
- 包括居住在瑞典的15-24岁的北欧出生的妇女.
- 考克斯回归分析用于计算抑郁症的调整危险比率 (AHR),控制共变量.
主要成果:
- 与LNG-IUD使用相关的抑郁症风险增加了57% (AHR 1.57).
- 青少年妇女和那些使用LNG-IUD作为第一种荷尔蒙避孕药的人显示出最高的风险增加.
- 风险估计随着时间的推移而下降,可能是由于可访问性增加和混因素.
结论:
- 开始使用LNG-IUD进行荷尔蒙避孕的青少年女性面临着更高的抑郁风险.
- 混因素可能会影响观察到的风险,因为估计在研究期间减少.
- 需要进一步调查,以确定LNG-IUD与抑郁症之间的确切因果关系.
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