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海星中第二个放松素类型的淋巴体活动

Masatoshi Mita¹, Yuling Feng², Victor M Piñon-Gonzalez²

¹Department of Biochemistry, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.

General and comparative endocrinology

|August 23, 2023

概括

海星利用两个不同的类似于放松素的,RGP1和RGP2,来调节产卵. 这些,类似于胰岛素,触发卵的成熟和释放,突出了皮繁殖中的双重荷尔蒙控制系统.

科学领域:

* * 海洋生物学海洋生物学
* 内分泌学在内分泌学.
* 生殖生物学生殖生物学

背景情况:

* 海星利用一种类似于放松素的性腺刺激 (RGP) 来控制伴生体的成熟和产卵.
*RGP与其他放松素/胰岛素超级家族一样,具有通过二硫化键连接的A和B链.
* RGP结构包括一个链内和两个链间的二硫化物键.

研究的目的:

* 为了识别和描述海星中的第二个放松素类 (RLP2).
* 研究RLP2在海星生殖过程中的作用.
* 为了比较RLP2的功能和结构与已知的RGP.

主要方法:

* 在Valvatida,Paxillosida和Forcipulatida类的海星物种中识别RLP2.
*分析RLP2前体结构,包括信号,C,A链和B链.
*使用P. pectinifera RLP2 (Ppe-RLP2) 和A. rubens RLP2 (Aru-RLP2) 进行体外药理学测定,以评估蛋脱落.
*RLP2的功效和物种特异性与RGP的比较.

主要成果:

* 在多个海星系中发现了一种新型的放松素类,RLP2.
*RLP2前体与RGP具有结构上的相似性,但在A链中具有独特的囊素基因.
*Ppe-RLP2和Aru-RLP2都有效地诱导了各自物种的卵子脱落,其效力与RGP相当.
* RLP2在其淋腺功能方面显示出部分物种特异性.

结论:

*两个不同的放松素类型,RGP和RLP2,调节海星的繁殖.
*这些发现表明,一种双重的荷尔蒙系统控制了这些海洋无脊椎动物的繁殖.
*建议将RGP和RLP2重新命名为RGP1和RGP2,以反映它们的不同角色.

关键词:

这是一种性腺激素 (gonadotropin).像Relaxin这样的淋巴腺刺激.这是一种类似于Relaxin的.诱导产卵的活动.海星是什么意思海星是什么意思

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