近几十年来,在全球范围内,Vibrio parahaemolyticus中抗微生物耐药性基因明显增加
Guan-Yu Fang1, Xing-Quan Liu1, Xiao-Jing Mu2
1College of Food and Health, Zhejiang A&F University, Hangzhou, 311300, PR China.
Chemosphere
|August 23, 2023
概括
随着时间的推移,Vibrio parahaemolyticus中的抗菌素耐药性 (AMR) 基因显著增加,而毒性因子基因减少,对人类健康构成持续风险. 移动遗传元素驱动AMR,与抗生素使用和人类发展有关.
科学领域:
- 微生物学 微生物学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 维布里奥帕拉海莫利蒂库斯 (Vibrio parahaemolyticus) 是一种具有增加抗微生物耐药性 (AMR) 的重要食物传播病原体.
- 全球AMR和V. parahaemolyticus病毒性趋势的大规模纵向研究有限.
- 了解这些趋势对于减轻公共卫生风险至关重要.
研究的目的:
- 从1951年到2021年,调查全球V. parahaemolyticus中抗生素耐药性基因 (ARG) 和病毒性因子基因 (VFG) 的纵向趋势.
- 识别导致AMR和毒性因素,包括移动遗传元素和社会经济指标.
- 开发用于评估全球AMR和VFG风险的预测模型.
主要方法:
- 对1540个V. parahaemolyticus隔离物的纵向分析,跨越70年.
- 使用分子方法量化ARG和VFG.
- 统计分析包括相关性,回归和结构方程建模.
- 随机森林建模用于风险预测和绘图.
主要成果:
- 随着时间的推移,在V. parahaemolyticus分离物中观察到ARG的显著增加和VFG的显著减少.
- 与人类相关的隔离物中的VFGs没有显著变化,表明持续的致病潜力.
- 移动遗传元素与ARG有很强的关联,但与VFG没有.
- 人类发展指数与抗生素消费和随后的AMR正相关.
结论:
- V. parahaemolyticus表现出越来越多的抗菌药物耐药性,由移动遗传元素驱动,并受到社会经济因素的影响.
- 尽管VFG的总体趋势正在下降,但人类隔离物中持续的毒性需要继续保持警.
- 这项研究为V. parahaemolyticus提供了一个全球风险评估框架,有助于制定有针对性的缓解策略.
相关概念视频
00:57Antibiotic Selection
54.7K
Overview
54.7K
01:30Development of Antibiotic Resistance
40
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
40
01:28Gene Regulation in Microbial Communities: Quorum Sensing
39
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
39
00:46Genomic DNA in Prokaryotes
44.0K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic Diversity in Bacteria
Although bacterial genomes are much...
44.0K
01:28Antimicrobial Effectiveness
48
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
48
01:23Stringent Response in E. coli
31
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
31