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骨关节炎年在审查中2023年:代谢物和蛋白质生物标志物

Ming Liu¹, Nafiza Haque¹, Jingyi Huang¹

¹Division of Biomedical Sciences (Genetics), Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.

Osteoarthritis and cartilage

|August 23, 2023

概括

最近的研究强调了骨关节炎 (OA) 的新代谢物和蛋白质生物标志物. 这些进展有助于理解OA的发病过程,并通过识别患者亚型来开发个性化的治疗方法.

科学领域:

生物化学生化学
分子生物学分子生物学
生物标志物发现发现

背景情况:

骨关节炎 (OA) 是一种退行性关节疾病,具有复杂的发病因子.
准确的生物标志物对于OA的早期诊断,预后和个性化治疗至关重要.

研究的目的:

在过去一年中,系统地审查和突出表现了对骨关节炎 (OA) 的代谢物和蛋白质生物标志物的进展.
确定新型生物标志物和生物标志物面板,用于OA诊断,严重程度,进展和治疗结果.

主要方法:

在五个主要数据库 (PubMed,Web of Science,Scopus,Ovid Medline,Embase) 进行全面的文献搜索,查找2022年4月至2023年3月期间发表的研究.
包括标准:原始研究,人类标本,英语,全文可用.
系统地提取和总结符合条件的研究数据.

主要成果:

46项研究符合来自1600个独特记录的纳入标准.
焦点领域包括OA生物标志物 (41项研究),OA聚类 (4项研究) 和治疗结果 (1项研究).
29个研究研究了蛋白质标记物,13个研究了代谢物标记物,四个研究了两者. 确定了新的生物标志物和面板,具有潜在的OA患者下设.

结论:

关于OA聚类的研究数量正在增加,这表明对患者分层的兴趣越来越大.
虽然临床应用需要在更大的队列中进行验证,但这些发现提高了对OA病原和治疗机制的理解.
已识别的生物标志物和面板对基于OA亚型的个性化治疗策略具有前景.

关键词:

生物标志物生物标志物代谢产物的代谢物骨关节炎是一种骨关节炎.蛋白质蛋白质是一种蛋白质.

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