睡眠功能障碍在年轻成年人中双向介导着下丘脑岛连接和焦虑抑郁症症状严重程度之间的关系
Guangfei Li1, Yu Chen2, Shefali Chaudhary2
1Department of Biomedical engineering, Faculty of Environment and Life, Beijing University of Technology, Beijing, China; Beijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Beijing, China.
NeuroImage
|August 23, 2023
概括
男性的睡眠质量差与下丘脑和内丘脑之间大脑连接的改变有关,影响焦虑和抑郁. 这些发现凸显了睡眠和情绪调节方面的潜在性别差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 人类大脑成像技术
背景情况:
- 下丘脑调节睡眠-清醒周期和有动机的行为.
- 睡眠障碍与认知和情绪障碍有关.
- 下丘脑功能障碍在这些缺陷中的确切作用尚不清楚.
研究的目的:
- 研究下丘脑休息状态功能连接 (rsFC) 与睡眠功能障碍之间的关联.
- 检查下丘脑 rsFC,睡眠质量,认知表现和情绪状态之间的关系.
- 通过调解分析,探索这些因素之间的相互关系.
主要方法:
- 使用了人类结合体项目的数据集 (N=687).
- 分析了与匹兹堡睡眠质量指数 (PSQI) 分数,认知表现和情绪相关的下丘脑 rsFC.
- 员工调解分析以评估相互关系.
主要成果:
- 在男性中,较高的下丘脑岛的rsFC与较差的睡眠质量相关 (PSQI得分).
- 无论是下丘脑岛的rsFC和PSQI得分都与男性的焦虑和抑郁症状有关.
- 在男性中,PSQI得分调解了下丘脑岛 rsFC 与焦虑/抑郁症状的双向关系.
结论:
- 睡眠功能障碍与改变的下丘脑岛 rsFC 和男性的负面情绪状态有关.
- 改变的下丘脑岛 rsFC 和焦虑抑郁症症状严重程度是通过睡眠质量差的双向相关.
- 研究结果表明,在调节睡眠和情绪的神经回路中,存在潜在的性别差异,这需要进一步调查.
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