在鼻腔中重建后,用鼻内喷雾剂输送嗅觉药物
Harry Chiang1, Hannah L Martin1, Ryan M Sicard2
1Department of Head and Neck Surgery & Communication Sciences, Duke University, Durham, NC, USA.
International journal of pharmaceutics
|August 23, 2023
概括
鼻腔中手术不会改善药物输送到嗅觉空气空间. 最佳的鼻内喷雾输送取决于较小的颗粒大小,较慢的喷雾速度和更高的吸入率,以有效的鼻至脑药物输送.
科学领域:
- 生物医学工程 生物医学工程
- 药理学 药理学是指药理学的学科.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 导电性嗅觉和鼻至脑药物输送至关重要,但由于解剖障碍和对嗅觉空气空间的不良准而受到阻碍.
- 目前的鼻内喷雾方法在有效地将气味物或药物输送到嗅觉区域方面面临挑战.
研究的目的:
- 研究鼻腔中手术对使用鼻内喷雾剂的嗅觉药物输送的影响.
- 通过计算流体动力学分析各种参数对嗅觉区域药物颗粒沉积的影响.
主要方法:
- 计算流体动力学 (CFD) 模拟被用于模拟从尸体标本重建的鼻腔气道中的空气流和药物颗粒运输.
- 模拟考虑了包括吸入率,喷雾速度和位置,头部位置和颗粒大小在内的因素.
- 模拟了鼻腔中手术技术 (软组织升高,扩散器,扩散器移植).
主要成果:
- 药物颗粒的嗅觉沉积总量通常很低 (<5%),但在因颗粒大小而优化时,可以达到高达36.33%.
- 鼻腔中手术与增强的嗅觉沉积之间没有发现显著的关联.
- 较小的颗粒大小,较低的喷雾速度和更高的吸入率表明了优化嗅觉沉积的趋势.
结论:
- 鼻腔中手术似乎没有通过鼻内喷雾增强药物输送到嗅觉区域.
- 优化鼻内喷雾参数,如颗粒大小,喷雾速度和吸入率,是改善嗅觉药物输送的关键.
- 这些发现为设计未来的鼻内药物输送系统提供了关键的见解,这些系统针对鼻至大脑应用的嗅觉空域.
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