定期放电加上脑电图上的快速活动,预测中风后的结果会更差
Kazuki Fukuma1, Maya Tojima2, Tomotaka Tanaka1
1Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan.
Epilepsia
|August 23, 2023
概括
在脑电图 (EEG) 上,具有快速活性 (PDs+F) 的周期性放电 (PDs) 与中风后 (PSE) 的功能衰退有关. 这些EEG模式可以预测后的短期和长期功能障碍.
科学领域:
- 神经学 神经学
- 的研究研究.
- 神经生理学 神经生理学
背景情况:
- 发作后功能衰退是患有中风后 (PSE) 的患者的一个重大问题.
- 有限的数据存在于电脑电图 (EEG) 标记器,预测PSE的功能衰退.
- 了解这些标志物对于管理患者和预测结果至关重要.
研究的目的:
- 调查EEG周期性放电 (PDs) 与PSE患者的功能衰退之间的关联.
- 为了探索功能衰退风险分层的PDs的特定EEG特征.
- 评估EEG标记物,成像检测结果和短期和长期功能衰退之间的关系.
主要方法:
- 观察性研究包括307名患有PSE的患者,他们接受了头皮EEG.
- 分析了PD和短期功能衰退 (在7天内) 之间的关联.
- 对EEG标志物进行了风险分层评估,并评估了与成像和长期功能下降 (出院后和6个月后) 的关联.
主要成果:
- 患有PD的患者与没有PD的患者相比,短期功能衰退的可能性更高 (20%对3.2%).
- 叠加快速活动的PDs (PDs+F) 与局部性病变和长时间的高 perfusion相关.
- PDs+F显著增加了短期 (OR=22.0) 和长期功能衰退 (OR=4.21) 的风险.
结论:
- 在EEG上具有快速活性 (PDs+F) 的周期性放电与PSE中持续的神经元激发和高 perfusion有关.
- 在PSE中,PDs+F可以作为在PSE中发作后短期和长期功能衰退的预测标志物.
- 这些发现强调了特定EEG模式在治疗中风后方面的预后价值.
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