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目前的情况:针对急性淋巴细胞白血病的全源性造血干细胞移植

Susan Prockop¹, Franziska Wachter¹

¹Pediatric Stem Cell Transplant Program, DFCI/BCH Center for Cancer and Blood Disorders, Pediatrics, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States.

Best practice & research. Clinical haematology

|August 23, 2023

概括

针对急性淋巴细胞白血病 (ALL) 的血造干细胞移植 (HCT) 进展迅速. 创新解决了复发,毒性和移植对宿主疾病 (GvHD) 等挑战,改善了患者的治疗结果.

科学领域:

血液学血液学血液学
在瘤学瘤学.
移植免疫学移植免疫学

背景情况:

针对急性淋巴细胞白血病 (ALL) 的血造干细胞移植 (HCT) 已经显著发展.
早期的挑战包括白血病复发,与治疗方案相关的毒性和移植对宿主疾病 (GvHD).

研究的目的:

审查目前对ALL患者的HCT的考虑和未来方向.
突出 донор选择,调节方案和GvHD管理方面的进展.

主要方法:

审查实验室发现及其转化为ALL中HCT的临床创新.
扩大捐赠者池 (无血缘关系,带血,单一) 和新型治疗剂的分析.

主要成果:

扩大供体来源和新药剂已经改善了HCT的可访问性和ALL的结果.
目前正在进行的研究重点是平衡毒性与疾病控制,预防GvHD和复发.

结论:

对ALL的HCT继续受益于研究迅速转化为临床实践.
未来的方向包括新的临床试验,通过管理GvHD和预防复发,进一步提高结果.

关键词:

成人的急性淋巴细胞白血病.异性血型造血干细胞移植是全源的.替代性捐赠者移植手术在HCT中,HCT是HCT.儿科急性淋巴细胞白血病患者.

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