针对性细胞疗法用于治疗复发性或耐药性白血病
Lauren D Scherer1, Rayne H Rouce1
1Texas Children's Cancer Center, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, USA.
Best practice & research. Clinical haematology
|August 23, 2023
概括
向免疫疗法,如CAR-T细胞,为复发性或耐火性白血病提供了一个有希望的,少毒的替代方案,特别是在干细胞移植失败后. 这些先进的细胞疗法正在重塑血液性恶性瘤治疗.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 全基性造血干细胞移植 (allo-HSCT) 是高风险或复发/耐药白血病的标准.
- 在allo-HSCT后复发的患者面临着不良预后,需要替代治疗.
- 向免疫疗法,特别是采用细胞疗法,是一个可行的选择.
研究的目的:
- 审查针对性细胞疗法用于复发性或耐药白血病的使用.
- 作为一个关键的例子,突出展示了仿真抗原受体T细胞 (CAR T细胞).
- 讨论其他正在研究的细胞免疫疗法和可扩展性考虑.
主要方法:
- 关于为白血病采用细胞治疗的现有文献的综述.
- 专注于CAR T细胞疗法,包括其临床反应和商业批准.
- 讨论其他细胞免疫疗法和后勤挑战.
主要成果:
- 收养细胞疗法为传统救援疗法提供了一种不那么有毒的替代方案.
- 卡尔T细胞在白血病中表现出了显著的持续临床反应.
- 这些疗法可以是alo-HSCT-enabling或移植不合格患者的选择.
结论:
- 有针对性的细胞疗法,特别是CAR T细胞,正在改变白血病治疗.
- 对于移植专业人士来说,了解这些复杂的疗法至关重要.
- 这些精密药物的可持续性和可扩展性需要进一步开发.
相关概念视频
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Stem Cell Therapy for Tissue Regeneration
4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Tumor Immunotherapy
556
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
556
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K


![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)