中枢静脉血压作为加快动脉硬度进展的危险因素
Takamichi Takahashi1, Hiroki Nakano1, Kazuki Shiina1,2
1Department of Cardiology, Tokyo Medical University.
Journal of atherosclerosis and thrombosis
|August 23, 2023
概括
升高的中央缩血压 (cSBP) 是中年日本男性加速动脉硬进展的重要危险因素. 这项研究证实了cSBP.
科学领域:
- 心血管生理学心血管生理学
- 动脉生物力学 动脉生物力学
- 高血压研究 高血压研究
背景情况:
- 由于波反射,静脉系统血压 (SBP) 通常从动脉中心向外围下降.
- 异常的压力波反射可以减弱这种梯度,导致中心SBP (cSBP) 的升高.
- 升高cSBP对动脉硬度进展的独立风险尚不清楚.
研究的目的:
- 调查升高的cSBP是否是加速动脉硬性进展的独立风险因素.
- 分析中年日本男性cSBP和动脉硬之间的关系.
- 使用潜增长曲线建模 (LGCM) 进行前性分析.
主要方法:
- 展望观察性研究9年.
- 涉及3862名中年日本男性,没有先前的脑心血管疾病.
- 每年测量脚脉冲波速 (baPWV) 和cSBP (辐射波形SBP2).
主要成果:
- 在随访期间 (6.3±2.5年) 观察到baPWV和SBP2的显著增加.
- 对LGCM的分析证实SBP2 (cSBP的标记物) 是每年baPWV变化的重要决定因素 (B=0.260,P<0.001).
- cSBP显著预测了动脉硬度进展的速度.
结论:
- 升高的中央缩血压是加速动脉硬度进展的独立危险因素.
- 这些发现支持cSBP在该人群中动脉硬的发展中的作用.
- 强调监测中年男性cSBP的重要性.
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