酒精消费和大脑小血管和大血管疾病:孟德尔的随机化分析
Takashi Hisamatsu1,2, Yasuharu Tabara1,3, Aya Kadota1
1Department of Public Health, Shiga University of Medical Science.
Journal of atherosclerosis and thrombosis
|August 23, 2023
概括
酒精消费与小血管疾病 (SVD) 中风风险增加有关,但大血管疾病中风风险降低. 这项研究使用ALDH2基因变异来探索酒精.
科学领域:
- 神经学 神经学
- 遗传学 遗传学是一种遗传学.
- 心血管医学 心血管医学
背景情况:
- 酒精摄入量与中风风险之间的关系是复杂的,并取决于中风类型.
- 阿尔代脱酶2基因 (ALDH2) 变体rs671影响酒精代谢和耐受性.
研究的目的:
- 研究酒精消费对大脑小血管疾病 (SVD) 和大血管疾病的因果关系.
- 为了利用ALDH2-rs671变体作为在孟德尔随机化分析中的遗传仪器.
主要方法:
- 在682名没有中风病史的男性中进行了横截面的门德尔随机化研究.
- 通过脑MRI评估SVDs (缺口性心脏病发作,白质强度过高,脑微出血) 和内动脉狭窄 (ICAS).
- 分析ALDH2-rs671基因型,酒精消费和脑血管疾病患病率之间的关联.
主要成果:
- 不活跃的ALDH2-rs671等位基因携带者比非A等位基因携带者消耗的酒精明显少.
- 非A基因基因携带者表现出更高的高血压率和更低的LDL胆固醇.
- 在非A等位基载体中观察到SVD的几率更高,而ICAS风险较低,尽管在同变量调整后关联减弱.
结论:
- 酒精消费与大脑SVDs的风险有积极的关联.
- 酒精摄入量似乎与大血管疾病风险相反相关,可能由高血压和LDL胆固醇等因素介导.
- 这些发现提供了关于将酒精消费与不同类型的中风联系在一起的因果途径的见解.
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