中老年和老年人的喘与气流阻塞的表型:CADSET临床研究合作
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Updated: Jul 18, 2025

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Published on: December 17, 2017
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Xander Bertels1,2, Ahmed Edris1,2, Judith Garcia-Aymerich3,4
1Department of Bioanalysis, Ghent University, Gent, Belgium.
BMJ open respiratory research
|August 23, 2023
概括
喘与气流阻塞 (AO) 是一种常见的呼吸道疾病. 这种表型与仅喘或仅COPD相比,更容易出现呼吸困难,心脏病风险增加和乙氨基酸细胞升高.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 肺部病理学 肺部病理学
- 临床的表型化 临床的表型化
背景情况:
- 喘与空气流阻塞 (AO) 的临床特征和患病率尚不清楚.
- 了解AO对于准确的诊断和管理至关重要.
研究的目的:
- 在大型人口和临床队列中以空气流阻塞 (AO) 为喘的表型.
- 为了比较AO与仅喘和仅COPD的临床概况和并发症.
主要方法:
- 一项针对50岁及以上的成年人 (N=69,789) 进行的横截式多队列研究,并采用了螺旋计数据.
- 根据喘诊断和FEV1/FVC比率<0.7.7定义的AO.
- 根据年龄,性别,吸烟状况和BMI调整的并发症的元分析.
主要成果:
- 在不同队列中,AO的患病率有所不同:以人口为基础的患病率为2.1%,以喘为基础的患病率为21.1%,以COPD为基础的患病率为16.9%.
- 患有AO的患者报告呼吸障碍较多,血中异氨基细胞数量较高.
- 与仅喘患者相比,AO患者更常是男性,吸烟者,BMI较低,并患有慢性支气管炎.
- 与仅有COPD的患者相比,AO患者更年轻,吸烟频率更低,包装年数更少.
结论:
- 带有空气流阻塞 (AO) 的喘是一种流行的呼吸系统表型.
- AO与呼吸障碍增加和冠状动脉疾病,抑郁症,骨质疏松症和GERD的风险增加有关.
- 在一般人群中,在AO患者中,血中氨基酸细胞数量升高更为常见.
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