抗生素预防预防干口和手术部位感染后的第三下部提取:一个网络的元分析
O Camps-Font1, H Sábado-Bundó2, J Toledano-Serrabona1
1School of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain; IDIBELL (Bellvitge Biomedical Research Institute), Barcelona, Spain.
International journal of oral and maxillofacial surgery
|August 23, 2023
概括
下第三提取后的抗生素预防可减少干口和手术部位感染. 然而,需要治疗的高人数表明,在处方之前,要仔细考虑患者的风险因素.
科学领域:
- 口腔和牙面部外科手术
- 药理学 药理学是指药理学的学科.
- 基于证据的牙科.
背景情况:
- 系统性抗生素通常在第三下部提取后被处方,以预防手术部位感染 (SSI) 和干.
- 在这种情况下,预防性抗生素的有效性和必要性需要持续评估.
研究的目的:
- 系统地审查和元分析随机临床试验,比较预防性抗生素用于第三下部提取.
- 评估不同抗生素对干,SSI和与抗生素相关的不良事件风险的影响.
主要方法:
- 随机临床试验的系统审查和对对/网络元分析.
- 包括16项试验,涉及2158名患者 (2428次提取).
- 分析了阿莫西西林,甲尼达,阿齐思罗米和克林达米.
主要成果:
- 抗生素的使用显著降低了干 (NNT=25) 和SSI (NNT=18) 的风险.
- 聚合结果有利于这些结果的抗生素预防.
- 还分析了与抗生素相关的不良事件.
结论:
- 抗生素预防是有效的降低干口和SSI率后下第三口提取后.
- 需要治疗的高人数需要谨慎的方法.
- 临床医生应根据患者的全身状况和感染风险对抗生素处方进行个性化.
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