细菌的脂多糖在结直肠瘤微环境中调节免疫反应
A K Sulit1,2, M Daigneault3, E Allen-Vercoe3
1School of Natural Sciences, Massey University, Auckland, New Zealand. iel_sulit@yahoo.com.
NPJ biofilms and microbiomes
|August 23, 2023
概括
肠道微生物组影响着结直肠癌 (CRC) 的进展. 来自Fusobacterium periodonticum的特定细菌脂多糖 (LPS) 刺激免疫反应,而来自Bacteroides fragilis和Porphyromonas asaccharolytica的细菌抑制它们,影响CRC亚型.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 结肠直肠癌 (CRC) 的结果受到免疫反应的影响,在共识分子亚型 (CMS) 中观察到明显的影响.
- 微生物组在CRC中的作用,特别是在不同的CMS中,尽管已知与癌症中的免疫活性有关,但仍未得到充分探索.
研究的目的:
- 研究肠道微生物组对CRC亚型中出现的相反免疫效应的贡献.
- 确定潜在的微生物机制,特别是脂多糖 (LPS) 相互作用,影响CRC中的免疫细胞活性.
主要方法:
- 综合宿主基因表达和CRC手术切除的元转录组数据.
- 将CRC样本亚型化为CMS,并分析相关的微生物群落.
- 隔离了细菌LPS,并测试了其对外周血液单核细胞 (PBMC) 中细胞因子产生的影响.
主要成果:
- Fusobacterium periodonticum LPS刺激了PBMC中的细胞因子生产,与CMS1.1相关.
- 细菌菌和 Porphyromonas asaccharolytica LPS 抑制了细胞因子的产生,与CMS4相关.
- 来自B. fragilis和P. asaccharolytica的LPS可以抵消F. periodonticumLPS的免疫刺激作用.
结论:
- CRC微生物组组成及其相关的LPS概况显著影响局部免疫活性.
- 微生物LPS可以差异调节免疫反应,为不同的CRC预后提供潜在的功能机制.
- 了解这些微生物与免疫相互作用对于开发有针对性的CRC疗法至关重要.
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