2型CD8+T细胞的形成依赖于互白素-33并与喘恶化有关
Esmee K van der Ploeg1,2, Lisette Krabbendam1, Heleen Vroman1
1Department of Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Nature communications
|August 23, 2023
概括
CD8+细胞毒性T细胞 (Tc细胞) 可以产生2型细胞因子,成为Tc2细胞. 这些细胞在严重的喘和恶化中升高,由IL-33驱动,并与更糟糕的疾病结果有关.
科学领域:
- 免疫学 免疫学 免疫学
- 呼吸系统医学 呼吸系统医学
- 细胞生物学 细胞生物学
背景情况:
- 2型细胞因子在过敏性喘中驱动慢性气道炎症,主要来自Th2和ILC2细胞.
- 已知具有抗病毒作用的CD8+细胞毒性T (Tc) 细胞也可以产生2型细胞因子,称为Tc2细胞.
- TC细胞在喘发病和恶化中的特定作用以及促进TC2细胞分化的信号尚不清楚.
研究的目的:
- 研究CD8+ Tc2细胞在严重喘和病毒引起的恶化中的作用和调节.
- 识别促进喘Tc2细胞形成的微环境因素和细胞类型.
- 探索向Tc2细胞通路的治疗潜力.
主要方法:
- 在严重喘患者和恶化期间分析循环Tc2细胞的丰度.
- 使用实验性过敏气道炎症的小鼠模型.
- 研究了传统的1型树突细胞,IFNγ和IL-33在Tc2细胞分化和功能中的作用.
主要成果:
- 在严重喘患者中观察到循环Tc2细胞数量的增加,在恶化期间达到峰值.
- Tc2细胞丰度与疾病严重程度,恶化频率增加和类固醇不敏感性相关.
- 鼠标模型展示了肺Tc细胞的2型倾斜,由cDC1s和IFNγ调节.
- 鉴定出interleukin-33 (IL-33) 是促进肺Tc细胞产生2型细胞因子的关键因素.
结论:
- CD8+ Tc细胞是严重喘和恶化的2型细胞因子的重要生产者.
- Tc2细胞形成是塑性的,可能来自IFNγ+ Tc细胞,对炎症微环境敏感.
- 在实验性过敏气道炎症中,IL-33是Tc2细胞分化的关键调节剂,突出了潜在的治疗标.
相关概念视频
T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma: Pathogenesis and Management
443
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
443
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
Asthma-I: Introduction
2.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K
T Cell Activation and Clonal Selection
806
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
806


