在COVID-19后持续的症状与差异性SARS-CoV-2抗体或T细胞免疫不相关
Daniel M Altmann1, Catherine J Reynolds2, George Joy3,4
1Department of Immunology and Inflammation, Imperial College London, London, UK. d.altmann@imperial.ac.uk.
Nature communications
|August 23, 2023
概括
在轻度SARS-CoV-2感染后适应性免疫的定量差异似乎不会导致长期Covid. 这项研究发现,有或没有持续症状的个体之间没有显著的免疫反应变化.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 长期Covid的致病性仍然不清楚,一些理论表明在急性SARS-CoV-2感染期间存在异常免疫反应.
- 研究初始免疫反应在发展持续症状中的作用对于了解长期Covid至关重要.
研究的目的:
- 分析患有轻度或无症状急性感染的医疗保健工作者对SARS-CoV-2的幽默和细胞免疫力.
- 为了比较患有持续症状 (长期Covid) 和没有症状的个体之间的免疫反应.
主要方法:
- 对抗体反应 (尖端RBD,核蛋白),病毒中和T细胞反应长度分析,感染后长达18周.
- 在感染1年后,两剂疫苗接种后,评估免疫特征.
- 86名实验室确认的SARS-CoV-2感染卫生保健工作者的分层,基于症状持续性.
主要成果:
- 在抗体水平,病毒中和能力或T细胞反应之间没有发现显著差异,直到感染后18周.
- 在持久症状和没有持久症状的个体中,抗体衰退的概况相似.
- 免疫反应在感染1年后,即使在接种疫苗后,在症状和无症状组之间仍然是可比的.
结论:
- 在轻度或无症状急性感染后测量适应性SARS-CoV-2免疫力的定量差异不太可能是长期Covid的直接原因.
- 这些发现表明,超出测量适应性免疫参数的因素可能是长期Covid发展的基础.
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