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循环停止与选择性前级大脑输液对大脑功能连接和术后认知功能的影响
Tae-Hoon Kim1, Jooyoung Oh2,3, Ha Lee4
1Department of Cardiovascular Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Scientific reports
|August 23, 2023
概括
带有循环停止 (CA) 的大动脉手术没有显著改变认知功能或妄想. 然而,它显示了大脑连接的亚临床变化,特别是在默认模式网络中.
科学领域:
- 神经科学是一个神经科学.
- 心血管外科心血管外科
- 认知功能 认知功能
背景情况:
- 大动脉手术是复杂的,可能导致认知后果.
- 术内循环停止 (CA) 是可能影响术后大脑功能的关键因素.
研究的目的:
- 为了研究CA的大动脉手术后休息状态功能连接 (rsFC) 的变化.
- 探索改变的rsFC和术后认知功能之间的关系.
主要方法:
- 功能磁共振成像 (fMRI) 用于在手术后5天评估38名患者的rsFC (14名有CA,24名没有) 的功能磁共振成像.
- 评估了手术后的认知变化和妄想.
- 分析了患有CA和没有CA的患者之间的rsFC差异.
主要成果:
- 两组之间没有观察到术后妄或认知功能障碍的显著差异.
- 患有CA的患者在默认模式网络中表现出增加的rsFC,包括后带状皮质和右上回,右前和右海马之间的连接.
- 在CA组中,也注意到中部前额叶皮层与背侧前额叶皮层的连接性增加.
结论:
- 中度低温CA与单边前级大脑输液并没有显著影响明显的术后认知变化.
- 在急性脑损伤后,CA可能会诱导默认模式网络rsFC中的亚临床变化.
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