脑卒中与疹眼科的关联
Angela S Gupta1, Tejus Pradeep1, Yinxi Yu2
1Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Philadelphia, Philadelphia, PA, USA.
Eye (London, England)
|August 23, 2023
概括
疹眼 (HZO) 在一年内将中风风险增加18%. 在HZO发作后的第一个月内,中风风险最高.
科学领域:
- 神经学 神经学
- 眼科医生 眼科 眼科
- 流行病学 流行病学
背景情况:
- 疹眼 (Herpes zoster ophthalmicus,简称HZO) 是一种已知与中风相关的病毒感染.
- 以前的研究表明存在联系,但需要严格控制混因素.
研究的目的:
- 为了验证HZO和中风之间的关联.
- 为了在全国范围内对美国人口进行医学并发症和社会因素的控制.
主要方法:
- 使用美国行政索赔数据库进行回顾性病例控制研究和自我控制病例系列 (SCCS).
- 考克斯比例危险回归与反比例治疗权重用于病例控制分析.
- 在SCCS中HZO诊断之前和之后的中风发病率的比较.
主要成果:
- 在HZO后1年内,人们观察到中风风险增加了18% (HR=1.18).
- 脑卒中风险在HZO发作后的一个月是最高的 (RR=1.58).
- 在HZO后的30天内,与HZO前的时期相比,中风风险明显增加.
结论:
- 证实了HZO与中风之间的关联,即使考虑到中风风险因素.
- 马上HZO后的时期具有最高的中风风险.
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