调节细胞死亡途径及其在平衡,感染,炎症和瘤发生中的作用
Ein Lee1, Chang-Hyun Song2, Sung-Jin Bae3
1Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, South Korea.
Experimental & molecular medicine
|August 23, 2023
概括
四个受调节的细胞死亡 (RCD) 途径,包括热,光,死和铁,对于恒温和宿主防御至关重要. 新出现的证据揭示了这些途径之间的交叉通话,导致了PANoptosis的概念,特别是在传染病和癌症中.
科学领域:
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 调节细胞死亡 (RCD) 路径,如热灭,灭,死灭和铁灭,对于清除受感染或瘤细胞,维持平衡,以及防御病原体至关重要.
- 这些通路在各种疾病中至关重要,包括癌症和传染病.
研究的目的:
- 检讨热,,死和铁的分子机制.
- 讨论这些RCD途径在维持恒常状态中的重要性.
- 探索RCD途径之间的交叉和PANoptosis的新兴概念,特别是在传染病和癌症中.
主要方法:
- 对遗传学和生物化学研究的文献综述.
- 对RCD通路的分子和细胞过程的分析.
- 专注于支持感染性疾病和癌症中的PANoptosis的证据.
主要成果:
- 不同的分子机制构成pyroptosis,apoptosis,necroptosis和ferroptosis的基础.
- 这些RCD路径之间存在显著的交叉通话和灵活性.
- 证据支持PANoptosis的概念化,这是一个联合途径,特别是在对感染的反应中.
结论:
- 了解RCD路径及其交叉通话对于维持健康和对抗疾病至关重要.
- PANoptosis的概念为细胞对感染和癌症的反应提供了新的见解.
- 对RCD机制的进一步研究可以为治疗感染,无菌炎症和癌症的新疗法的开发提供信息.
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