免疫景观和HPV相关结直肠癌中的菌生物:一项探索性研究

Maria Raffaella Ambrosio1, Elena Niccolai2, Federica Petrelli1

  • 1Pathology Unit, Azienda USL Toscana Nord Ovest, Pisa, Italy.

概括

人类乳头瘤病毒 (HPV) 感染与20-40%的结直肠癌 (CRC) 有关,影响瘤发育和免疫反应. 阳性CRC呈现出不同的微生物群和改变的瘤微环境.

相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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