在帕金森病中,布拉迪基尼西亚和刚性由主要运动皮质和白球之间的功能连接调节
Kaoru Kinugawa1, Tomoo Mano2,3, Shigekazu Fujimura4
1Department of Neurology, Nara Medical University, 840 Shijo-Cho, Kashihara, Nara, 634-8521, Japan.
Journal of neural transmission (Vienna, Austria : 1996)
|August 23, 2023
概括
帕金森病 (PD) 脑网络中的功能连接 (FC) 在药物"开启"和"关闭"状态之间有所不同. 异常的皮层-状皮层FC,特别是涉及前中心和白色球体,与PD的运动症状严重程度相关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 帕金森病 (PD) 中的运动波动尚未完全理解.
- 大脑刺激会影响运动症状,但其与功能连接 (FC) 的联系尚不清楚.
研究的目的:
- 调查PD患者在药物"开启"和"关闭"状态下运动症状严重程度和脑网络FC之间的关系.
- 通过静止状态功能磁共振成像 (rsfMRI) 探索FC和运动障碍之间的相关性.
主要方法:
- 在26名偶发性PD患者中使用rsfMRI评估FC.
- 在"开启"和"关闭"状态下使用MDS-UPDRS第三部分评估运动症状严重程度.
- 使用皮尔森相关系数分析了FC和MDS-UPDRS Part III分数之间的相关性.
主要成果:
- 在"开启"和"关闭"状态之间,FC-运动症状相关性显著不同.
- 在"关闭"状态下,前中心 (PreCG) 和球 (GP) 之间的FC与总运动分数和勃拉迪基尼西亚/刚性相关.
- 侧面分析显示,对侧面PreCG-GP FC与"关闭"状态下的运动症状相关.
结论:
- 在皮层-状回路中的异常FC与PD中的运动症状严重程度有关.
- 皮层-状层的超连接性,特别是在运动通路 (PreCG-GP) 中,有助于PD的运动障碍.
- 这些发现可能会增强对PD机制的理解,并为大脑刺激疗法提供信息.
相关概念视频
Parkinson's Disease: Overview
596
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
596
Parkinson's Disease: Treatment
297
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
297
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K
Brainstem
2.2K
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
2.2K
Direct Motor Pathways
2.1K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
2.1K


