尼克尔暴露与糖尿病的关联:来自观察研究的证据
Weihang Xia1, Xianwei Guo1, Peng Xie1
1Department of Epidemiology and Health Statistics, School of Public, Health Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.
Environmental science and pollution research international
|August 23, 2023
概括
环境中的暴露,特别是尿液中的,与患糖尿病的风险增加有关. 在这次元分析中,血水平与糖尿病风险没有显著的关联.
科学领域:
- 环境流行病学环境流行病学
- 毒理学 毒理学 毒理学
- 代谢性疾病研究研究.
背景情况:
- 关于人类暴露与糖尿病风险之间的联系存在争议.
- 环境流行病学研究在暴露和糖尿病发病率方面提供了不同的结果.
研究的目的:
- 进行一项元分析,调查暴露与糖尿病风险之间的关联.
- 为了澄清这种关系,使用来自多项研究的汇总数据.
主要方法:
- 在PubMed,Web of Science和Embase数据库进行系统搜索,截至2023年5月.
- 使用随机效应模型进行元分析,以计算聚合赔率比率 (OR) 和95%置信区间 (CI).
- 使用受限立方线进行剂量反应分析,以评估尿水平和糖尿病风险.
主要成果:
- 包括12项研究,共30 018名参与者.
- 尿中含量较高与糖尿病风险增加有关 (OR 1.42,95% CI 1.14-1.78).
- 每增加1μg/L的尿与7%的糖尿病风险增加相关 (OR1.07,95%CI1.04-1.10).
- 在血中含量和糖尿病风险之间没有发现显著的关联 (OR1.03,95% CI 0.57-1.86).
结论:
- 尿中暴露与糖尿病风险增加正相关.
- 血水平与糖尿病风险没有显著的关联.
- 建议进行进一步的高质量的前性研究来证实这些发现.
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