患有生命限制状况或虚弱的患者的口腔干燥:两个干预研究和一个嵌套定性子研究 (干燥口腔项目,DROP) 的研究方案
Annelot I van der Meulen1, Evelien P J G Neis2, Ellen J M de Nijs3
1Center of Expertise in Palliative Care, Leiden University Medical Center, Leiden, Netherlands. aivandermeulen@lumc.nl.
BMC palliative care
|August 23, 2023
概括
这项研究评估了一项由护士主导的教育计划和治疗息治疗中口腔干燥的皮洛卡尔. 这两种干预措施都显示出改善口腔干燥症状和生活质量的前景.
科学领域:
- 抚慰性护理是一种缓解性护理.
- 症状管理 症状管理
- 临床研究 临床研究
背景情况:
- 口腔干燥 (xerostomia) 是患有限制生命状况或虚弱的患者普遍但未得到充分治疗的症状.
- 缺乏意识,知识和有效的干预措施,导致口腔干燥的管理不足.
- 干燥口腔项目 (DRy mOuth Project,简称DROP) 调查了这种脆弱人群中干燥口腔的新型干预措施.
研究的目的:
- 调查非药理 (护士领导的患者教育计划) 和药理 (局部应用的皮洛卡尔) 对口腔干燥的干预措施的有效性和可行性.
- 评估这些干燥口腔干预措施对口腔干燥严重程度,生活质量和患者/专业人员经验的影响.
- 评估在息护理环境中实施这些干预措施的成本效益和可行性.
主要方法:
- 两项并行研究:一个由护士领导的患者教育计划 (MEP) 与常规护理的集群非随机对照试验,以及局部应用皮洛卡尔滴的双盲安慰剂对照随机试验.
- 混合方法设计,主要结果是4周的临床反应 (口腔干燥严重程度得分).
- 二次结果包括持久性,生活质量,坚持性,可接受性,可行性和成本效益,通过问卷,重点小组和采访在12周内进行评估.
主要成果:
- 主要结局:通过口腔干燥严重程度得分来衡量4周内干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥干燥
- 二次结果:效果的持久性,对生活质量的影响,干预措施的坚持和可接受性.
- 通过医疗保健专业人员和患者反来评估可行性和成本效益.
结论:
- 这项研究旨在确定两种不同的干燥口腔干预措施在息护理中的有效性和可行性.
- 这些发现将增强对口腔干燥,其导致因素以及患者/专业人员对护理和指导方针的经验的理解.
- 这项研究将提供基于证据的策略,以改善患者的干燥口腔症状管理限制生命条件或脆弱.
相关概念视频
02:07Blind Procedures
10.7K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
10.7K
01:26Assessment of the Mouth
251
A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
251
01:26Longitudinal Studies
187
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
187