老年男性患者中CCTA评估的TyG指数和冠状动脉样硬化之间的相关性:一个横截面研究
Xiaona Wang1, Xinqiang Ji2, Jianhui Yu1
1Department of Cardiology, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China.
Diabetology & metabolic syndrome
|August 23, 2023
概括
高龄男性的甘油三糖 (TyG) 指数与冠状动脉样硬化无关. 血红蛋白A1c (HbA1c%) 是冠状动脉疾病 (CAD) 严重程度和阻塞性冠状动脉疾病 (CVD) 的重要因素.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 老年病的医生 老年病的医生
背景情况:
- 年龄是复杂冠状动脉疾病 (CAD) 的重要危险因素,老年患者的预后较差.
- 代谢障碍在老年人中很常见,有助于CAD发病率和死亡率.
- 调查老年人CAD风险的新生物标志物至关重要.
研究的目的:
- 为了检查甘油三糖指数 (TyG) 和整体冠状动脉样硬化负担之间的关联.
- 评估TyG指数作为老年人群中阻塞性冠状动脉疾病 (CVD) 的风险因素的作用.
主要方法:
- 对427名接受冠状动脉计算机断层扫描血管图 (CCTA) 的患者进行了回顾性横截面研究.
- 根据莱登得分分层的患者 (≥5比<5).
- 相关性和回归分析 (斯皮尔曼,物流,线性) 以评估TyG指数和HbA1c%与莱登得分和阻塞性心血管疾病相比.
主要成果:
- 在高 (≥5) 和低 (<5) 莱登分数组之间没有观察到TyG指数的显著差异.
- 泰格指数与莱登得分 (r=0.05,p=0.42) 或阻塞性心血管疾病 (β=0.39,p=0.13) 没有相关性.
- HbA1c%与莱登得分 (r=0.44,p<0.01) 有正相关性,是阻塞性心血管疾病的独立预测因子 (β=1.86,p<0.01).
结论:
- 在老年男性中,TyG指数与冠状动脉样硬化负担或阻塞性心血管疾病没有显著的相关性.
- 在这个人群中,HbA1c%是冠状动脉疾病严重程度和阻塞性心血管疾病的重要影响因素.
- 与TyG指数相比,HbA1c%可能是老年人CAD风险的更可靠指标.
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