评估乙型肝炎消除计划对印尼西爪的母婴健康的影响:一项跨部门研究
Anita Deborah Anwar1, Annisa Dewi Nugrahani1, Dhanny Primantara Johari Santoso1
1Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Faculty of Medicine Padjadjaran University, Dr. Hasan-Sadikin General Hospital, Bandung, West Java, Indonesia.
概括
乙型肝炎病毒 (HBV) 疫苗接种显著降低了感染母亲出生的新生儿的感染风险. 虽然检测覆盖率很好,但及时的婴儿疫苗接种对于印度尼西亚的HBV消除计划至关重要.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 在怀孕期间感染乙型肝炎病毒 (HBV) 存在向新生儿垂直传播的风险.
- 了解干预的有效性至关重要,特别是在研究不足的地区.
- 这项研究评估了印度尼西亚加鲁特地区的HBV消除计划.
研究的目的:
- 评估针对孕妇和新生儿的HBV消除计划的有效性.
- 确定影响母婴HBV传播的因素.
- 评估HBV疫苗接种对婴儿结局的影响.
主要方法:
- 对100名HBsAg阳性孕妇和62名后代进行的截面研究.
- 使用快速测试套件 (双面三明治测试免疫染色学) 确定HBsAg状态.
- 使用单变量,双变量和多重回归逻辑分析分析的数据.
主要成果:
- 16.95%的女性最初被诊断为HBsAg阴性,在转诊时检测出阳性.
- 接种HBV疫苗的婴儿显示出明显较低的HBsAg阳性状态 (P=0.029).
- 母亲变量与后代HBsAg状态相关;疫苗显示具有保护作用 (OR=0.326).
结论:
- 该研究在孕妇中实现了高HBsAg测试覆盖率.
- 在HBsAg阳性母亲的婴儿中,婴儿乙型肝炎疫苗接种率未达到目标.
- 乙型肝炎病毒疫苗是面临垂直传播风险的婴儿的关键防御.
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