血细胞淋巴细胞细胞瘤的生物疗法:当前的知识和未来的前景
Lingbo He1, Chun Yang1, Yini Wang1
1Department of General Practice, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Expert opinion on biological therapy
|August 24, 2023
概括
生物疗法为血细胞淋巴细胞细胞瘤 (HLH) 患者提供了新的希望,改善了缓解率并减少了毒性. 虽然有希望,但仔细监测是必不可少的,因为它们有时会恶化或触发HLH.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 血性淋巴细胞细胞瘤 (HLH) 是一种严重的高炎症综合征,预后不佳.
- 不同导致HLH的原因都有一个共同的特征:细胞因子过剩.
- 针对细胞因子的生物疗法正在成为HLH的关键治疗方式.
研究的目的:
- 审查和总结目前对HLH的生物治疗选择.
- 突出生物疗法在治疗耐火性或化学疗法不耐受性HLH病例中的作用.
主要方法:
- 对血细胞淋巴细胞瘤的生物治疗策略的文献综述.
- 对生物疗法的疗效和安全性进行临床数据和专家意见的分析.
主要成果:
- 生物疗法为复发性/耐药性HLH患者或对化疗不耐受患者提供了替代方案.
- 与传统疗法相比,生物药物提高了反应率,延长了缓解期,并降低了与治疗相关的毒性.
- 组合生物制剂具有前景,但由于潜在的不良影响,需要谨慎应用.
结论:
- 生物疗法代表了HLH管理的重大进步,提供了更好的结果.
- 在使用生物药物时,特别是在组合使用时,仔细选择和监测患者至关重要.
- 对优化HLH生物治疗策略的进一步研究是有必要的.
相关概念视频
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Microorganisms in Medicine and Therapeutics
54
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
54
Cytotoxic T Cells-mediated Immune Response
965
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
965
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Tumor Immunotherapy
556
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
556


