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阿根廷的脑膜炎球菌疾病负担:10年流行病学综述

Silvina Neyro¹, Analia Urueña², Adriana Efron³

¹Dirección de Control de Enfermedades Inmunoprevenibles, Ministerio de Salud de la Nación, Buenos Aires, Argentina.

Human vaccines & immunotherapeutics

|August 24, 2023

概括

侵入性脑膜炎球菌病 (IMD) 主要影响婴儿,发病率在2013年达到峰值,随后下降. 疫苗接种计划对于保护B和W等主导血清组至关重要.

科学领域:

流行病学流行病学
疫苗学疫苗学疫苗学
公共卫生公共卫生

背景情况:

侵入性脑膜炎球菌病 (IMD) 是一种严重的,可能致命的感染,不成比例地影响婴儿.
阿根廷在2017年为婴儿和青少年实施了针对A,C,W和Y血清组 (MenACWY) 的国家疫苗接种计划.

研究的目的:

分析2010年至2019年期间阿根廷IMD的流行病负担.
评估IMD发病率,死亡率,病例死亡率以及MenACWY疫苗引入后血清组分布的趋势.

主要方法:

利用国家监测数据库收集和分析2010-2019年IMD病例数据.
估计的发病率,死亡率,病例死亡率和不同年龄组的血清组流行率.
在研究期间,跟踪了血清组识别和分布的变化.

主要成果:

报告共有1972例IMD病例,在1岁以下的婴儿中观察到的发病率最高.
2013年IMD发病率达到峰值,随后下降;婴儿的死亡率明显高于婴儿.
血清组B (48%) 和W (42%) 是最常见的,近年来血清组B显著增加,特别是在婴儿中.

结论:

IMD流行病学是动态的,主要血清组的变化被观察到.
早期疫苗接种对于保护婴儿免受流行和新兴血清组的侵害至关重要.
数据支持基于证据的医疗保健决策,用于IMD预防和控制.

关键词:

阿根廷阿根廷阿根廷阿根廷阿根廷.孩子孩子孩子孩子疾病负担疾病负担脑膜炎球菌病是脑膜炎球菌的疾病.血清组是血清组的组成部分.

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