硫氧化物通过在败血症期间在内皮细胞中通过葡萄糖重塑改善血管透性
Jiayun Ying1, Caiyan Zhang1, Yaodong Wang1
1Department of Critical Care Medicine, Children's Hospital of Fudan University, Shanghai, China.
Frontiers in immunology
|August 24, 2023
概括
硫氧化物治疗减少了合成甘-1 (SDC1) 脱落,改善了内皮屏障功能和儿科败血症休克的存活率. SDC1水平预测了败血症儿童的预后.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 医学研究 医学研究
背景情况:
- 内皮葡萄糖的降解在败血症相关的肺损伤和血管透性中至关重要.
- 调查硫氧化物在血清重塑和败血症期间内皮壁障碍功能障碍中的作用.
研究的目的:
- 确定硫氧化物是否可以预防内皮质糖核体损伤,并改善败血症中的内皮质屏障功能.
- 评估儿童败血症休克中syndecan-1 (SDC1) 的预后价值.
主要方法:
- 在28名患有感染性休克的儿童中测试了血海帕兰硫酸盐和SDC1.
- 已建立的细胞和小鼠败血症模型来评估硫氧化物的影响.
- 在败血症模型中测量了内皮壁功能,蛋白质表达,存活率和肺损伤.
主要成果:
- 循环中的SDC1水平与死亡率和儿科败血症休克中的IL-6水平相关.
- 通过NF-κB/ZO-1通路,SDC1脱落增加了内皮通透性;硫氧化物抑制了脱落,并改善了通过NF-κB/ZO-1通路的屏障功能.
- 在小鼠败血症模型中,使用硫氧化物增加了存活率,减少了肺损伤,并恢复了葡萄糖.
结论:
- 对于患有败血症休克的儿童来说,SDC1是预后生物标志物.
- 硫二氧化物证明了与败血症相关的内皮功能障碍的治疗潜力.
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