在印度生育年龄妇女中,各种血清激素参数的规范范围:ICMR-PCOS工作组研究结果研究结果
Mohd Ashraf Ganie1,2, Subhankar Chowdhury3, Vanita Suri4
1Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India.
The Lancet regional health. Southeast Asia
|August 24, 2023
概括
这项研究确定了生殖年龄的健康印度女性关键激素的生物参考间隔. 几种激素的年龄特异性变化被发现,为临床解释提供了关键数据.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 临床生物化学 临床生物化学
背景情况:
- 荷尔蒙特征表现出明显的变化,受年龄,性别,种族,饮食和生理状态的影响.
- 有限的特定人群数据存在于健康妇女的荷尔蒙变化.
- 了解这些变异对于准确的健康评估至关重要.
研究的目的:
- 为了确定各种荷尔蒙参数的生物参考间隔在生育年龄的健康印度妇女.
- 为印度未来的研究和临床实践提供基础数据集.
- 在这个人群中识别与年龄相关的荷尔蒙特征差异.
主要方法:
- 对3877名参与者的临床和生化分析,对1441名受试者的实验室研究.
- 用标准化方法在单一中心进行的激素分析.
- 排除了593名表格异常或数据不完整的受试者,最终共计848名女性.
主要成果:
- 已建立血清T4,TSH,益生菌,LH,FSH,丸激素,禁食胰岛素,皮质醇,DHEAS和SHBG的参考间隔.
- 在益乳素,FSH,丸激素,C-胰岛素和DHEAS (p <0.05) 中观察到与年龄相关的显著变化.
- 在不同人群中观察到规范性激素范围的边际差异.
结论:
- 这项研究提供了第一个关于印度生育年龄妇女激素措施的大型综合数据.
- 这些已确定的参考间隔对于准确诊断和对该人群内分泌疾病的管理至关重要.
- 这些发现凸显了对某些激素的特定年龄基准范围的需要.
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