儿童2型糖尿病中超大胞性高血糖状态的危险因素
Estelle M Everett1,2,3, Timothy Copeland4, Lauren E Wisk2,4
1Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
在儿童2型糖尿病中,超的高血糖状态 (HHS) 比糖尿病酸性酸症 (DKA) 不太常见,但与更高的严重程度和死亡率有关. 男性性别和黑人种族是HHS的风险因素.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 糖尿病是一种糖尿病.
背景情况:
- 关于在2型糖尿病 (T2D) 儿科中区分超的高血糖状态 (HHS) 与糖尿病酸症 (DKA) 的风险因素的数据有限.
- 了解这些差异对于管理T2D年轻人的高血糖紧急情况至关重要.
研究的目的:
- 识别和比较与HHS相关的风险因素与T2D儿科患者的DKA入院.
- 在这个人群中分析HHS和DKA之间的严重程度和死亡率差异.
主要方法:
- 利用国家儿童住院患者数据库 (2006-2019) 来识别儿童T2DDDKA和HHS的入院情况.
- 使用描述性统计学,奇二测试和后勤回归来评估相关因素和结果.
- 不包括9岁以下的患者.
主要成果:
- 在儿童T2D中8,961例因高血糖紧急情况入院的病例中,有6%是HHS,94%是DKA.
- 与DKA相比,HHS入院在男性 (OR 1.77) 和黑人青年 (OR 1.81) 中更常见.
- 医疗卫生和公共服务部门的入院患者患重病的几率 (11.3倍) 和死亡率 (5.0倍) 显著上升.
结论:
- 虽然DKA更频繁,但HHS在儿科T2D中代表了更严重的高血糖紧急情况.
- 在这个人口群体中,男性性别和黑人种族被确定为HHS的风险因素.
- 需要进一步的研究来阐明这些差异的根本原因.
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