在诊断出心血管疾病后患癌症的风险
Caitlin F Bell1,2,3, Xiudong Lei4, Allen Haas4
1Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.
JACC. CardioOncology
|August 24, 2023
概括
心血管疾病 (CVD) 增加了癌症的风险. 动脉硬性心血管疾病 (aCVD) 特别与较高的癌症发病率有关,包括特定类型的肺癌和结肠癌,即使考虑到其他危险因素.
科学领域:
- 心血管医学 心血管医学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 心血管疾病 (CVD) 和癌症具有共同的风险因素.
- 临床前数据表明,心血管疾病加速癌症,但对动脉样硬化和癌症风险的临床证据有限.
研究的目的:
- 调查心血管疾病,特别是动脉样硬化心血管疾病 (aCVD) 与发生癌症风险之间的独立关联.
主要方法:
- 来自IBM MarketScan索赔数据的超过2700万无癌症个体的分析.
- 根据心血管疾病的存在和类型分层 (动脉样硬化与非动脉样硬化).
- 对心血管风险因素进行多变量调整的时间变量分析.
主要成果:
- 患有心血管疾病的人患癌症的风险高出13% (HR:1.13).
- 与非ACVD相比,aCVD与更大的癌症风险相关 (HR: 1.20).
- aCVD显示与肺,膀,肝脏,结肠和血液癌症的特定关联.
结论:
- 心血管疾病与癌症风险增加有关.
- 动脉样硬化可能导致这种关联,特别是在特定的癌症亚型中,独立于传统的风险因素.
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