纤维细胞标记物加列-3识别了患癌症和心力衰竭风险的男性
Pieter F van den Berg1, Joseph Pierre Aboumsallem1, Elles M Screever1
1Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
JACC. CardioOncology
|August 24, 2023
概括
纤维化生物标志物加勒-3 (gal-3) 的增加与男性的新癌症和心力衰竭 (HF) 有关. 这种关联在女性中没有观察到,这表明性别特异性疾病机制.
科学领域:
- 心血管医学 心血管医学
- 在瘤学瘤学.
- 生物标志物研究 生物标志物研究
背景情况:
- 癌症和心力衰竭是导致死亡的主要原因.
- 共同的机制,如纤维化,可能会将这些疾病联系在一起.
- 这种关系的性别特异性尚未得到充分理解.
研究的目的:
- 研究纤维化生物标志物加勒-3 (gal-3) 在预测新发癌症和高血压性肺炎中的作用.
- 为了确定这些关联是否在男性和女性之间有所不同.
主要方法:
- 在PREVEND研究的5,786名参与者中测量了加勒-3水平.
- 在4年内,Gal-3的显著增加 (≥50%) 被评估.
- 性别分层的考克斯回归分析评估了11.5年来与新发癌症和HF的关联.
主要成果:
- 在男性中,高高的gal-3水平与新发癌症 (HR:1.89) 和新发HF (HR:1.77) 有显著的关联,即使在调整了多种危险因素之后.
- 这些关联对于男性的特定癌症亚型仍然很重要.
- 在女性中,Gal-3水平的变化与新发癌症或HF无关.
结论:
- 加列-3的升高是男性新发癌症和心力衰竭的重要预测因素.
- 对于这些情况,gal-3的预测价值在女性中并不明显.
- 研究结果表明,癌症和HF的发展有性别特异性路径,可能由纤维化介导.
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