在生活方式中介的减肥过程中,DNA甲基化的影响
Samantha Aurich1,2, Luise Müller1, Peter Kovacs1,3
1Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
Frontiers in endocrinology
|August 24, 2023
概括
肥胖是一个日益严重的全球健康问题,受遗传学和环境的影响. 生活方式干预在改变与肥胖相关的表观遗传模式方面表现有前途,但需要更多的研究来确定特定的DNA甲基化生物标志物.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 肥胖问题研究研究
- 公共卫生 公共卫生
背景情况:
- 在过去的50年里,全球肥胖患病率急剧上升,这对公众健康构成了重大挑战.
- 肥胖是多因素的,涉及遗传,表观遗传和环境因素之间的复杂相互作用.
- 目前对导致肥胖风险的生物学机制的理解尚不完整.
研究的目的:
- 审查人类干预研究,检查生活方式对与肥胖相关的DNA甲基化的影响.
- 评估有针对性的干预措施在修改与肥胖相关的表观遗传模式方面的潜力.
- 确定对肥胖预防和治疗的表观遗传生物标志物未来研究的需求.
主要方法:
- 对19项最近关于生活方式和肥胖相关DNA甲基化的人类干预研究的系统综述.
- 对记录体重减轻干预期间表观遗传标记物变化的研究进行分析.
- 在干预的背景下,专注于表观基因组范围的关联研究 (EWAS) 和甲基组范围的关联研究 (MWAS).
主要成果:
- 生活方式干预表明有可能改变与肥胖相关的表观遗传模式.
- 减肥干预可以诱导与肥胖相关的DNA甲基化变化.
- 干预研究提供了一种强大的方法来研究肥胖表观遗传学中的因果关系.
结论:
- 有针对性的生活方式干预具有改变与肥胖相关的表观遗传标记的巨大潜力.
- 进一步的大规模,强大的研究对于确定肥胖的特定DNA甲基化生物标志物至关重要.
- 通过干预来理解表观遗传重编程可以为个性化预防和治疗策略提供信息.
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