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Updated: Jul 18, 2025

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
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评估终点方法预测蛋白质激酶抑制剂的结合亲和倾向的能力

Martiniano Bello1, Cindy Bandala2

  • 1Laboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotecnológica, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Diaz Mirón s/n, Col. Casco de Santo Tomas Ciudad de México 11340 Mexico bellomartini@gmail.com mbellor@ipn.mx.

RSC advances
|August 24, 2023
PubMed
概括

像MMGBSA和MMPBSA这样的计算方法可以预测酶突变对结合亲和力的影响. 使用MMGBSA进行的长分子动力学模拟与EGFR抑制剂复合物的实验数据有很好的相关性.

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