肠道微生物组在肝细胞癌中的作用:系统性审查
Yash Trivedi1, Zoryana Bolgarina2, Heet N Desai1
1Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus
|August 24, 2023
概括
肠道微生物组失调与肝细胞癌 (HCC) 有关. 本综述探讨了肠肝轴和微生物组在HCC发育,诊断和治疗中的作用.
科学领域:
- 胃肠道学和肝病学
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 肠道微生物组失调在慢性肝病中很普遍,包括肝细胞癌 (HCC).
- 肠肝轴显著影响肝病的发展和进展.
- 了解肠道微生物组的作用对于管理HCC至关重要.
研究的目的:
- 系统地审查有关肠道微生物组在HCC病变发生过程中的作用的文献.
- 评估肠道微生物组改变在HCC的诊断潜力.
- 探索针对肠道微生物组进行HCC治疗的治疗含义.
主要方法:
- 按照PRISMA 2020指南进行的系统审查.
- 在PubMed,Cochrane图书馆,谷歌学者和ScienceDirect搜索了2013年5月2023年5月发表的研究.
- 包括17项研究,在选2969篇文章和质量评估后进行了17项研究.
主要成果:
- 肠道微生物组失调与HCC的发展和进展有关.
- 特定的微生物特征可以作为HCC诊断的潜在生物标志物.
- 调节肠道微生物组显示出作为HCC的辅助治疗的前景.
结论:
- 肠道微生物组在肠肝轴和HCC中发挥着至关重要的作用.
- 需要进一步的研究来将这些发现转化为HCC诊断和治疗的临床应用.
- 准肠道微生物组代表了肝细胞癌的新疗法策略.
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