微观结肠炎中的便calprotectin水平:系统性审查和元分析
Busara Songtanin1, Chanaka Kahathuduwa1, Kenneth Nugent1
1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
概括
便中calprotectin (FCP) 在患有微观结肠炎 (MC) 的患者中中度升高. 这一发现表明,FCP可能有助于识别慢性腹患者的MC.
科学领域:
- 胃肠病学 胃肠病学
- 临床诊断 临床诊断 临床诊断
- 炎症性肠道疾病研究研究
背景情况:
- 显微性结肠炎 (MC) 缺乏特定的生物标志物,需要通过结肠镜和组织病理学进行诊断.
- 有限的研究存在于便calprotectin (FCP) 在诊断MC的作用.
研究的目的:
- 评估便calprotectin (FCP) 作为显微大肠炎 (MC) 的潜在生物标志物的实用性.
- 为了比较MC患者和慢性腹患者的FCP水平.
主要方法:
- 在PubMed,Embase和Scopus上进行了系统的文献搜索,直到2022年9月.
- 使用随机效应元分析 (DerSimonian-Liard) 来比较MC患者和对照人群之间的FCP水平.
主要成果:
- 分析包括了六项研究,包括96名MC患者和200名对照.
- 与对照人群相比,MC患者的便calprotectin (FCP) 发现显著和中度升高 (SMD = 0.6).
- 研究之间的异质性在统计学上并不显著 (I2 = 41%).
结论:
- 慢性腹患者的FCP水平升高可能有助于识别患有微观结肠炎 (MC) 的患者.
- 建议进一步研究涉及连续FCP测量,以充分了解其在MC的诊断效用.
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