在儿科IgA血管炎中严重的胃肠道参与:中国的一项回顾性单中心队列研究
Yifan Li1, Xiaomei Zhang1, Haimei Liu1
1Department of Rheumatology, Children's Hospital of Fudan University, National Center for Children's Health, Shanghai, China.
Frontiers in pediatrics
|August 24, 2023
概括
在中国儿童中,严重的胃肠道 (GI) 参与IgA血管炎 (IgAV) 是常见的. 诸如年轻年龄,吐和特定实验室结果等因素预测严重的胃肠道问题,需要密集治疗.
科学领域:
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
背景情况:
- IgA 血管炎 (IgAV) 是最常见的儿童血管炎.
- 胃肠道 (GI) 症状在IgAV中很常见,从轻微的症状到严重的并发症.
- 了解严重胃肠道干预的风险因素对于及时干预至关重要.
研究的目的:
- 描述中国IgAV住院儿童肠道干扰的特征.
- 确定与儿科IgAV患者严重胃肠道干扰相关的临床和实验室因素.
主要方法:
- 对1179名住院IgAV患者的回顾性审查 (2014年1月至2020年12月).
- 根据出血和并发症,患者被分为严重和非严重的胃肠道群体.
- 分析临床特征,实验室数据和治疗策略.
主要成果:
- 50%的患者患有胃肠道干扰;其中48.9%患有严重的胃肠道干扰.
- 严重的胃肠道干扰的危险因素包括罕见的发病年龄 (<3或13-17岁),腰部以上的紫外线,吐,高中性粒细胞对淋巴细胞的比率和低血清白蛋白.
- 严重的胃肠道组显示出更高的脏干扰和炎率,需要更高的皮质类固醇剂量和更多的二线治疗.
结论:
- 严重的胃肠道干扰是儿科IgAV的一个重大问题.
- 早期识别风险因素可以指导管理.
- 患有严重胃肠道症状的患者需要积极的治疗,包括更高的皮质类固醇剂量和潜在的二线药物.
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