在局部前列腺癌患者中因癌症风险分层而导致的心血管死亡率:基于SEER的研究
Zehao Luo1,2, Kaiyi Chi1,2, Hongjun Zhao2,3
1Department of Endocrinology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Frontiers in cardiovascular medicine
|August 24, 2023
概括
心血管疾病 (CVD) 死亡率是局部性前列腺癌 (PCa) 的男性的主要死亡原因. 患有PCa的患者比普通人群面临心血管疾病死亡的风险更高,强调需要综合护理.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 在局部性前列腺癌 (PCa) 患者中,心血管疾病 (CVD) 的死亡风险尚不清楚.
- 风险分层对于了解疾病特异性结果至关重要.
研究的目的:
- 根据风险分层来确定局部PCa患者心血管疾病死亡的风险.
- 分析CVD作为PCa管理中的竞争风险.
主要方法:
- 使用SEER数据库 (2004-2016) 进行基于人口的研究.
- 对340,806个局部PCa病例的分析.
- 利用竞争性风险模型和标准化死亡率 (SMR) 来量化心血管疾病风险.
主要成果:
- 与心血管疾病相关的死亡是局部PCa患者死亡的主要原因.
- 与高风险相比,心血管疾病死亡率在低风险和中等风险组中早些时候超过了PCa死亡率.
- 局部PCa患者的CVD相关死亡率明显高于一般人群 (SMR范围从4.8到13.6).
结论:
- 心血管疾病在局部PCa管理中代表着一个主要的竞争风险.
- 累积心血管疾病死亡率随着生存时间的增加而增加,并在所有风险层中超过PCa死亡率.
- 针对PCa和CVD的综合管理对于这些患者至关重要.
相关概念视频
Cancer Survival Analysis
383
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
383
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Disorders of the Male Reproductive System
457
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
457


