来自胎盘的细胞外囊从前性怀孕损害血管内皮功能通过莱克类氧化LDL受体-1通过乳素
Roberto Villalobos-Labra1,2,3, Ricky Liu1,2,4, Floor Spaans1,2
1Department of Obstetrics and Gynecology (R.V.-L., R.L., F.S., T. Sáez, A.Q., C.-L.M.C., S.T.D.), University of Alberta, Edmonton, Canada.
Hypertension (Dallas, Tex. : 1979)
|August 24, 2023
概括
孕前-STBEVs通过激活LOX-1引起内皮功能障碍. 用TS20抗体阻断LOX-1 (乳类氧化低密度脂蛋白受体-1) 阻止这种功能障碍,这表明LOX-1是孕前的治疗点.
科学领域:
- 心血管生物学 心血管生物学
- 生殖医学 生殖医学
- 分子医学是分子医学.
背景情况:
- 孕前症涉及母亲的血管功能障碍.
- 产卵前的胎盘中产生的同聚热细胞衍生的细胞外囊 (STBEVs) 诱导内皮功能障碍.
- 细胞内膜传递介质LOX-1 (乳素样氧化低密度脂蛋白受体-1) 在产前-STBEV诱导的功能障碍中的作用尚未被探索.
研究的目的:
- 调查LOX-1是否调解由孕前-STBEVs引起的内皮功能障碍.
- 探索参与这个过程的下游信号通路.
- 评估针对LOX-1的治疗潜力.
主要方法:
- 从胎盘透物中分离出孕前-STBEVs.
- 在体外研究中使用了人类带静脉内皮细胞,这些细胞被治疗了先兆子-STBEVs和LOX-1阻断抗体 (TS20).
- 活体研究评估了大鼠中腔动脉的血管功能,使用线路肌图.
主要成果:
- 抑制LOX-1减少了孕前-STBEV的吸收,并防止了ERK激活,NF-κB激活和酸性应激.
- 在小鼠动脉中,TS20治疗预防了因子宫前-STBEVs引起的内皮依赖性血管扩张障碍.
- 抑制NOX (尼古丁胺胺氨基二核酸氧化酶) 或添加超氧化物失调酶恢复了血管功能.
结论:
- 洛克斯-1调解由孕前-STBEVs诱导的内皮功能障碍.
- 这项研究阐明了导致妊娠前并发症的机制.
- 洛克斯-1代表了孕前干预的潜在治疗标.
相关概念视频
01:26Coronary Artery Disease II: Pathophysiology
12
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
12
01:24Regulation of Angiogenesis and Blood Supply
2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
01:07Development of Blood Vessels
638
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
638