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在轻度和重度的COVID-19患者中血小板功能受损
Mariangela Scavone1, Claudia Ghali1, Mariagrazia Calogiuri1
1Divisione di Medicina Generale II, ASST Santi Paolo e Carlo, Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy.
即使是轻度疾病的COVID-19患者,也表现出异常的血小板功能. 这些血小板异常,在危急病例中更严重,通常在感染后恢复正常.
科学领域:
- 血液学 血液学 血液学
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 在严重的COVID-19中已知有血小板功能异常.
- 有限的数据存在于轻度COVID-19和复苏后的血小板功能.
- 了解血小板行为对于管理COVID-19并发症至关重要.
研究的目的:
- 在急性感染期间调查轻度和重度COVID-19患者的血小板参数.
- 为了评估COVID-19恢复后的血小板功能变化.
- 为了比较轻度和严重的COVID-19病例和健康对照之间的血小板异常.
主要方法:
- 在轻度COVID-19 (n=51),严重COVID-19 (n=49) 和健康对照组 (n=43) 中评估了血小板参数.
- 通过光传递聚合计评估循环活化血小板,δ-颗粒含量 (ADP,血清素) 和血小板活化.
- 在流量条件下测量血小板血栓形成 (300/s剪切率) 在原涂层表面.
主要成果:
- 无论是轻度还是重度的COVID-19患者都显示激活血小板的增加和血小板功能受损 (颗粒含量降低,原激活和血栓形成).
- 在严重的COVID-19患者中,异常更为明显.
- 61%的轻度病例和73%的严重病例至少表现出一个异常的血小板参数.
- 在康复小组 (n=13) 中,11名患者感染后至少一个月血小板参数正常化.
结论:
- 轻度血小板参数异常发生在轻度COVID-19患者急性感染期间,类似于严重病例,但程度较小.
- 在大多数患者从COVID-19中临床康复后,血小板功能通常会恢复正常.
- 这些发现突显了COVID-19在疾病严重程度上对血小板功能的系统影响.
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