在慢性鼻炎和下呼吸道疾病中非2型和混合炎症
Austin Heffernan1, Amir Shafiee1, Teffran Chan1
1Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, University of British Columbia, Vancouver, Canada.
The Laryngoscope
|August 24, 2023
概括
非2型炎症在具有下呼吸道疾病的慢性鼻炎 (CRS) 中起着重要作用,影响治疗结果. 了解这些不同的炎症特征对于开发有效的生物疗法至关重要.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 慢性鼻炎 (CRS) 和下呼吸道疾病经常同时存在.
- 2型炎症一直是生物疗法的焦点,但结果可能不够理想.
- 非2型炎症途径可能对疾病的呈现和进展作出重大贡献.
研究的目的:
- 讨论CRS和并发性下呼吸道疾病患者非2型炎症的作用.
- 对统一呼吸道疾病中的内型变异的现有证据进行审查.
- 为复杂的呼吸系统疾病的未来生物发展提供信息.
主要方法:
- 根据PRISMA-ScR指南进行全面的范围审查.
- 在多个数据库 (Medline,Embase等) 中进行了广泛的文献搜索. ) 的情况.
- 纳入标准侧重于气道采样,非2型细胞因子,以及患有CRS和下呼吸道疾病的患者.
主要成果:
- 很大一部分患有CRS和并发性喘,阿司匹林恶化呼吸道疾病 (AERD) 和慢性阻塞性肺病 (COPD) /支气管病的患者表现出混合或非2型末型.
- 末型变化在各种疾病中各不相同,CRS和喘呈现1型,2型,3型和混合模式.
- 患有COPD/支气管切开症的AERD和CRS也表现出不同的非2型炎症概况.
结论:
- 在患有统一呼吸道疾病的患者中,非2型炎症很普遍.
- 低于最佳的治疗结果可能是由于忽视了非2型炎症成分.
- 识别这些多样化的炎症内型对于推进有针对性的生物疗法至关重要.
更多相关视频
08:30Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
2.0K
11:54Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
30.4K
相关概念视频
01:23Chronic Pharyngitis
2.7K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
2.7K
01:26Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:17Drugs Used in Lower Respiratory Disorders: Overview
487
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
487
01:16Drugs Used in Upper Respiratory Disorders: Overview
290
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
290
01:31Common Respiratory Disorders
667
Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
667