2021年8月至11月的SARS-CoV-2血清流行率和疫苗覆盖率:2021年墨西哥全国代表性调查
Ana Basto-Abreu1, Martha Carnalla1, Leticia Torres-Ibarra1
1Center for Population Health Research, National Institute of Public Health, Cuernavaca, Mexico.
Journal of medical virology
|August 24, 2023
概括
在墨西哥,2021年底,有74%的成年人接种了SARS-CoV-2疫苗. 接种疫苗增加了抗S抗体的患病率,但老年人和接种特定疫苗的人的反应较低,这表明需要增强剂.
科学领域:
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 评估疫苗覆盖率和血清流行率对于了解人口免疫力至关重要.
- 墨西哥的疫苗接种活动旨在减轻SARS-CoV-2的影响.
研究的目的:
- 估计墨西哥的自我报告的疫苗覆盖率和SARS-CoV-2抗N和抗S血清流行率.
- 分析不同疫苗类型和不同人口群体的血清发病率.
主要方法:
- 一项针对7236名成年人 (≥18岁) 的全国代表性调查,使用干血斑点样本 (2021年8月至11月).
- 根据免疫试验灵敏度和特异性调整的抗N和抗S血清流行率的估计.
- 多变量波松回归以评估按疫苗类型和年龄组的血清流行率,并对混因素进行调整.
主要成果:
- 疫苗接种覆盖率达到74%,女性,高SES,毕业生和正式工人的比例更高.
- 抗N血清流行率为59.2%,而抗S血清流行率为84.1%,在接种疫苗的人群中更高.
- 所有疫苗显示>70%的抗S血清流行率;CoronaVac和Ad5-nCoV的发病率较低. 老年人 (≥60) 的血清流行率低于年轻人.
结论:
- 接种疫苗显著增加了墨西哥成年人的抗S抗体检测.
- 对于60岁以上的个人和那些接种了CoronaVac或Ad5-nCoV的疫苗的人,由于血清发病率较低,建议给予增剂剂量.
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