子宫内膜异位症 - 一种痛苦的疾病
Lydia Coxon1, Emma Evans, Katy Vincent
1Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Current opinion in anaesthesiology
|August 24, 2023
概括
了解子宫内膜异位症相关疼痛的进展正在改善治疗选择. 对于对子宫内膜异位症疼痛患者进行个性化,多学科的护理,需要进一步的研究.
科学领域:
- 妇科 妇科医生 妇科
- 疼痛医学 医学 疼痛医学
- 神经科学是一个神经科学.
背景情况:
- 子宫内膜异位症是一种慢性炎症性疾病,影响生殖年龄的女性.
- 与子宫内膜异位症相关的疼痛 (EAP) 显著影响生活质量.
- 目前对EAP机制的理解正在发展,超出了 nociception.
研究的目的:
- 审查了解子宫内膜异位症疼痛机制的最新进展.
- 为了概述与子宫内膜异位症相关的疼痛的最新治疗选择.
- 评估基础科学和临床试验结果在子宫内膜异位症研究中的整合.
主要方法:
- 临床试验和元分析的系统审查.
- 对目前关于子宫内膜异位症疼痛机制的文献进行分析.
- 对手术和荷尔蒙疗法的治疗疗效的评估.
主要成果:
- 对EAP的理解已经扩大到包括神经病变性和脑内可塑性疼痛机制.
- 手术治疗和荷尔蒙疗法已经证明了其有效性.
- 在子宫内膜异位症的基础科学研究和临床试验应用之间存在分离.
结论:
- 在理解EAP方面取得了重大进展,受到慢性疼痛研究的影响.
- 对所有子宫内膜异位症患者进行个性化,整体和多学科治疗仍然是一个遥远的目标.
- 进一步的研究对于弥合基础科学和临床实践之间的差距至关重要,以改善子宫内膜异位症的管理.
更多相关视频
相关概念视频
Disorders of the Female Reproductive System
406
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
406
Oogenesis
63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K
Menses Phase
306
The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
306
Appendicitis-I: Introduction
234
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
234
Inflammatory Bowel Disease II: Crohn's Disease
290
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
290
Chronic Pancreatitis I: Introduction
112
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
112


