在母体SARS-CoV-2疫苗接种后,母乳中的抗体反应持续和增强
Julie Ware1, Kathryn McElhinney2, Teresa Latham2
1Division of General and Community Pediatrics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
概括
哺乳期母亲的COVID疫苗接种是安全有效的,在母乳中产生持续的抗体反应. 孕产妇COVID-19疫苗接种支持母乳养母亲的普遍免疫接种,包括增强剂.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 母婴健康 母婴健康
背景情况:
- COVID-19疫苗临床试验最初不包括孕妇和哺乳期妇女.
- 评估母乳中的抗体水平对于了解哺乳期患者疫苗的益处至关重要.
研究的目的:
- 在接种疫苗后评估哺乳期妇女血清和母乳中的抗COVID-19抗体.
- 研究COVID-19疫苗接种对哺乳期和抗体反应的影响.
主要方法:
- 对63名哺乳期妇女进行前性纵向监测队列研究 (ADVISE试验).
- 在初始,第二次和强剂COVID-19疫苗剂量后收集的配对血清和母乳样本.
- 测量分泌IgA (sIgA) 和IgG抗体标位和病毒中和活性.
主要成果:
- COVID-19疫苗接种诱导了母乳中具有中和活性的显著的sIgA和IgG抗体.
- 抗体标位在第二剂后增加,在第三剂后仍然升高,即使在延长哺乳期.
- 没有发现抗体标位与母亲特征或疫苗类型之间的关联;在婴儿循环中没有检测到牛奶抗体.
结论:
- 哺乳期的母体COVID-19疫苗接种耐受性良好,并诱导母乳中强烈,持续的抗体反应.
- 这些发现支持普遍的COVID-19疫苗接种和哺乳期母亲的增强免疫接种,包括那些超过12个月的母乳养.
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