MERCURY-3:一个随机比较的netarsudil/latanoprost和bimatoprost/timolol在开放角玻璃眼和眼睛高血压
Ingeborg Stalmans1,2, Kin Sheng Lim3, Francesco Oddone4
1Department of Ophthalmology, University Hospitals UZ Leuven, Louvain, Belgium. ingeborg.stalmans@mac.com.
概括
固定剂量组合netarsudil/latanoprost (NET/LAT) 眼滴在降低开角玻璃眼和眼睛高血压时的眼内压力方面与比马托普罗斯特/蒂莫洛尔 (BIM/TIM) 没有劣势. 这两种治疗都显示出相似的安全性.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 视角大眼镜 (OAG) 和眼高血压 (OHT) 是全球不可逆转失明的主要原因.
- 有效的眼内压力 (IOP) 降低对于管理OAG和OHT至关重要.
- 固定剂量组合 (FDC) 眼滴为患者提供了方便和改善了患者的坚持.
研究的目的:
- 为了比较netarsudil 0.02%/latanoprost 0.005%眼部溶液 (NET/LAT) 与bimatoprost 0.03%/timolol maleate 0.5%眼部溶液 (BIM/TIM) 的疗效和安全性.
- 评估NET/LAT作为OAG和OHT的潜在替代FDC治疗方法.
主要方法:
- 一项为期6个月的前性,双面罩,随机,多中心,主动对照,并行组,非劣等性研究 (MERCURY-3).
- 包括患有OAG或OHT的患者 (≥18岁),其局部药物控制不足 (IOP≥17 mmHg和<28 mmHg).
- 患者被随机分配为每天一次的NET/LAT或BIM/TIM,并通过第3个月在多个时间点评估IOP.
主要成果:
- NET/LAT在IOP降低方面与BIM/TIM不逊色,在所有时间点的差异≤1.5 mmHg,在大多数时间点的差异≤1.0 mmHg到第3个月.
- 平均白天内血压在各组之间是可比的 (15.4-15.6 mmHg用于NET/LAT,15.2-15.6 mmHg用于BIM/TIM).
- 副作用一般为轻度/中度;常见的与治疗相关的副作用包括结膜性高血症 (NET/LAT 30.7%) 和角膜垂直化 (NET/LAT 11.0%).
结论:
- 每天一次的NET/LAT在OAG和OHT的IOP降低方面不低于BIM/TIM.
- NET/LAT的安全概况与之前的研究结果一致.
- NET/LAT为患有OAG和OHT的患者提供了可行的FDC治疗选择.
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