慢性多发性候群症的概况:临床病理学研究
Orit Winocur-Arias1, Ayelet Zlotogorski-Hurvitz2,3, Yehonatan Ben-Zvi3,4
1Department of Oral Pathology, Oral Medicine and Maxillofacial Imaging, Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel. orit_winocur@yahoo.com.
Virchows Archiv : an international journal of pathology
|August 24, 2023
概括
慢性多发性候群病 (CHC) 和白血病有相似的低恶性转变率. 系统性因素,如免疫状况和先前的癌症治疗,可能会使个体易患心血管疾病.
科学领域:
- 口腔病理学 口腔病理学
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
背景情况:
- 慢性多囊性候群病 (CHC) 和白血病是常见的口腔病变.
- 了解它们的恶性转变潜力对于患者管理至关重要.
研究的目的:
- 为了比较CHC的临床表现,系统性因素和长期恶性转变率与无发育不良的白血病相比.
- 确定与这些口腔病变及其结果相关的因素.
主要方法:
- 在2000年至2013年间诊断的116名患者进行了回顾性病例对照研究.
- 包括心血管疾病和白血病没有失生症的组.
- 对口腔恶性转变的长期随访 (至2022年),分析临床和显微镜数据.
主要成果:
- 与白血病相比,CHC病变的白色较少,并且更常见于性或异位性病变.
- 冠状动脉瘤组有较高的头恶性瘤史,化疗,放射治疗和免疫相关疾病的患病率.
- 恶性转变率在两组中都很低且相似 (3.2%的CHC,3.7%的白血病).
结论:
- 免疫相关的疾病,先前的头恶性瘤,放射治疗和化疗可能会导致CHC.
- 慢性血栓瘤的恶性转变率很低,相当于没有发育不良的白血病.
- 对CHC的观察到的转化率低于预期.
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