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在侵袭性乳腺癌妇女中缺乏受体状态的组件

Julie A Stephens¹, James L Fisher², Robert Wesolowski³

¹Center for Biostatistics, Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus.

JAMA network open

|August 24, 2023

概括

对雌激素受体,孕受体和ERBB2状态的测试对于乳腺癌 (BC) 治疗至关重要. 这项研究发现,4.7%的侵入性BC病例缺乏这种必要的受体状态信息,突出了关键的护理差距.

科学领域:

在瘤学瘤学.
公共卫生公共卫生
健康差异在健康上的差异

背景情况:

准确的乳腺癌 (BC) 亚型取决于雌激素受体 (ER),孕激素受体 (PR) 和ERBB2 (以前称为HER2) 测试.
在BC亚型的差异显著影响患者的结果和治疗策略.
尽管制定了指导方针,但BC患者记录中经常缺少受体状态信息.

研究的目的:

为了识别被诊断患有侵袭性乳腺癌的女性患者,他们缺乏ER,PR或ERBB2受体状态的记录.
在侵袭性BC病例中定义和量化受体状态缺失组件 (MCRS) 的患病率.

主要方法:

一项采用国家癌症研究所的监测,流行病学和最终结果 (SEER) 计划数据的横截面研究.
包括2012年1月至2016年12月期间在18个基于人口的注册表中诊断的侵入性BC病例.
多变量后勤回归分析以确定与MCRS相关的因素,包括年龄,种族,阶段,报告来源,付款人和地理位置.

主要成果:

在321,913例侵入性BC病例中,4.7% (15,250) 患有MCRS.
在老年女性 (≥80岁) 中,黑人女性比白人女性更为普遍,远程/无阶段的疾病.
仅通过实验室,护理/临终关怀设施或医生办公室报告的病例显示MCRS的几率更高.

结论:

显著比例的侵袭性乳腺癌病例缺乏基本受体状态测试,这表明在遵守标准护理方面存在差距.
需要有针对性的干预措施来提高激素受体和ERBB2测试率,特别是在脆弱人群中.
解决MCRS对于减少健康差异和改善乳腺癌患者的治疗结果至关重要.

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