科学证据是足够的吗? 使用专家意见来填补抗菌素耐药性研究数据的空白
Melanie Cousins1, E Jane Parmley2, Amy L Greer2
1School of Public Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.
PloS one
|August 24, 2023
概括
专家的见解收集,以解决了解抗菌素耐药性 (AMR) 驱动因素的数据差距. 这些半定量数据,来自欧洲"一健康"的背景下,有助于模拟AMR的出现和传播.
科学领域:
- 一个健康,一个健康.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 抗微生物药物耐药性 (AMR) 给全球健康和经济带来了重大挑战.
- 定量数据缺口阻碍了有效的抗药性反应建模和模拟.
- 专家知识可以弥合这些数据缺口,以便更好地了解AMR驱动因素.
研究的目的:
- 确定有关驱动AMR的因素的可量化的数据.
- 确定AMR驱动因素之间的关系的优势和方向.
- 利用欧洲一个健康系统的专家意见.
主要方法:
- 在瑞典举办的专家研讨会的成绩单的二次分析.
- 专注于欧洲食品系统背景中的专家.
- 识别半定量数据以参数化AMR模型.
主要成果:
- 专家陈述提供了关于AMR驱动因素的半定量数据.
- 获得了对影响AMR的因素当前状况的见解.
- 这项研究探讨了各种AMR驱动因素之间的关系.
结论:
- 专家的见解提供了有价值的数据,而定量信息很少.
- 这些发现为未来的AMR出现和传播模型提供了信息.
- 这项研究有助于理解瑞典一个健康系统中的AMR.
相关概念视频
Antibiotic Selection
54.7K
Overview
54.7K
Development of Antibiotic Resistance
40
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
40
Antimicrobial Effectiveness
48
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
48


